Infectious Disease Symposium

Clinicians should distinguish between true infection and situations mimicking infections that need only limited or no antibiotic therapy

Antibiotics can badly affect our body organs

A complete classification that includes the origin of source of infection, the anatomical extent of infection, the presumed pathogens involved and risk factors for major resistance patterns, and the patient’s clinical condition is exist

Which statement is false regarding the indication of Combined antibiotic therapy :

The drug should be selectively toxic for whatever microorganism is infecting us and to kill our own cells

Risk Factors for Colonization with Extended-Spectrum β-Lactamase–producing Bacteria

Shifting IV to oral antibiotics depending on disease stat and patient condition

The drug should be selectively toxic for whatever microorganism is infecting us and to kill our own cells

Polymicrobial infections like in secondary peritonitis, but more likely to involve resistant bacteria most common on

Antibiotic therapy should be as brief as possible in order not to compromise overall efficacy, and de-escalation or narrowing the spectrum of antibiotic therapy, should be performed as soon as antimicrobial sensitivity data are available

Which of the following is true about colistin

For adults with extra-biliary high severity complicated infections meropenem, doripenem, piperacillin/tazobactam, ciprofloxacin or levofloxacin in combination with metronidazole

Which of these organisms are the most common:

Which of following PD parameter best predicts colistin efficacy

.H., a 65-year-old woman (65 kg), was recently intiated on tobramycin and piperacillin/tazobactam for the treatment of hospital-acquired pneumonia.
After the first tobramycin dose of 120 mg (infused from noon to 1:00 p.m.), serum tobramycin concentrations are drawn. They are 4.4 mg/L at 3:00 p.m and 1.2 mg/L at 7:00 p.m. Which is the best assessment regarding the calculation of tobramycin pharmacokinetic parameters in this patient

All of the statement is consider a principles in choosing the antimicrobial therapy except:

Loading dose is not usually required since colistin’s half-life is short and it reaches steady state levels within few hours

P.L. is a 60-year-old woman (60 kg) recently initiated on gentamicin and clindamycin. After the first gentamicin dose of 110 mg (infused from 6:00 p.m. to 6:30 p.m.), serum gentamicin concentrations are drawn. They are 3.6 mg/L at 7:30 p.m. and 0.9 mg/L at 11:30 p.m. Which is the best assessment of this patient’s gentamicin pharmacokinetic parameters?

The principles of management of antimicrobial resistance are :

In case of RRT (renal replacement therapy):

R.K., a 39-year-old man who is HIV (human immunodeficiency virus) positive, receives a diagnosis of cryptococcal meningitis and begins taking amphotericin B and flucytosine. You want to keep flucytosine peak concentrations between 50 and 100 mcg/mL. Assuming a trough concentration of 25 mcg/mL, dosing every 6 hours, and 100% bioavailability, which is the best dose to achieve a peak concentration within the desired range (flucytosine volume of
distribution of 0.7 L/kg and half-life of 3 hours)?

Common hospital-acquired infections are:

Some patient populations require special dosing considerations because of having a state of systemic inflammation

Antibiotic MICs coupled with pharmacodynamic dosing strategies resulted in improved outcomes and shorter duration of treatments

In critically ill patients, such as those in septic shock, empiric therapy should be initiated immediately after or concurrently with collection of diagnostic specimens.

Augmented renal clearance (ARC) has been described in critically ill patients, where increased elimination of antibiotics lead to sub-therapeutic concentrations

The new definition of sepsis is as life-threatening organ dysfunction caused by a dysregulated host response to infection

Hospital-acquired infections are frequently related to the presence of invasive devices and procedure, clinicians should consider in use antibiotic:

Ertapenem, a highly protein-bound (85%-95%) carbapenem, yielded markedly larger volume of distribution and lesser total clearance in patients with hypoalbuminemia and sepsis, compared with healthy individuals

Sepsis is

In gram-positive outer cell membrane are suggested as posses intermediates in the transition between monoderm

Therapeutic drug monitoring of has expanded to include β-lactams, quinolones, linezolid and colistin

we need new definitions for sepsis

Delafloxacin is newly FDA approved fluoroquinolone for treatment of MRSA

Ventilator-associated pneumonia (VAP) is defined as pneumonia that presents after endotracheal intubation directly

Early and effective antimicrobial treatment Increase the survival rate

All antibiotics are used in treatment of pseudomonas except :

Risk of factors associated with developing surgical site infection

Carbapenems are the best antimicrobial agent for infections caused by such organisms

Central Line Associated Blood Stream Infection (CLABSI) is a laboratory-confirmed bloodstream infection in a patient where the central line was in place for > 2 calendar days (48 hours)* on the date of the event, with day of device placement being Day 1

Antibiotic therapy for critically ill patients with bacteremia due to carbapenemase-producing Klebsiella spp is

catheter associated urinary tract infections can lead to such complications as

The term antibiotic has sometimes been defined as a substance produced by microbes or artificially manufactured to inhibit the growth of microbes, especially bacteria.

Antibiotic resistance will destroy our future if no new generations

the most common Gram negative resistant bacteria .all are correct except: